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Trichloroisocyanuric acid (TCCA)–TMSOTf: an efficient activator system for glycosylation reactions based on thioglycosides

3-Arylselanyl- and 3-arylsulfanylindoles were prepared in EtOAc, by the reaction of indole with the diaryl dichalcogenide–Trichloroisocyanuric Acid (TCCA) reagent system. The products were efficiently and conveniently obtained, at room temperature and in short reaction times. 
Trichloroisocyanuric acid (TCCA), a readily available, inexpensive and shelf-stable reagent, in combination with a catalytic amount of TMSOTf, has been used for the first time for efficient glycosylation reactions based on thioglycoside donors with SEt, SPh and S-pTol leaving groups at the anomeric centres. Tertiary amines and their salts in dichloromethane were found to induce a strong para regioselectivity in the chlorination of anisole as the model substrate with trichloroisocyanuric acid (TCCA). Using a catalyst loading of 6 mol % trimethylammonium chloride gave a para vs. ortho selectivity of 38:1. This effect is attributed to the in situ formation of N-chlorotrialkylammonium salts, which chlorinate alkyl aryl ethers with a high regioselectivity. The regioselectivity and monochlorination selectivity for anisole chlorination with TCCA in numerous solvents are reported. The chlorination of a few related benzenoid substrates under selected conditions is described.
Trichloroisocyanuric Acid (TCCA) referred to TCCA. According to reports, TCCA is a new and efficient fungicide fungi, viruses were suppressed, killing effect; for the prevention and treatment of a serious impact on fisheries production Grass bacterial diseases, received good results. TCCA used in aquaculture, do pond in the natural food organisms affect it? We did toxicity test, TCCA endure degree, in order to understand the impact of TCCA on zooplankton.