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Trichloroisocyanuric Acid (TCCA) N-debenzylation described for the first time

The enantiospecific total synthesis of the δ-lactonic marine natural product (+)-tanikolide (1), isolated from Lyngbya majuscula, was achieved using a [2,3]-Meisenheimer rearrangement as the key reaction. During this rearrangement, we discovered that the allylic amine N-oxide could direct the m-CPBA double-bond epoxidation to the syn position. The resulting syn product 8 underwent epoxide ring opening under the m-CBA conditions to give the five- and six-membered cyclic ether amine N-oxides, which we further treated with Zn and conc. HCl to obtain the reduced bisbenzyl tertiary amines 23 and 22, respectively. When 23 and 22 were treated with trichloroisocyanuric acid (TCCA) in 
dichloromethane, oxidation at the benzyl position occurred, forming iminium ions. These intermediates were trapped by intramolecular reaction with the hydroxyls, and the resulting intermediates were then oxidized or shifted to afford 25 and 24, respectively. The entire one-pot process involves N-debenzylation, N-chlorination, and hemiacetal oxidation. The amine N-oxide-directed epoxidation complements Davies’ ammonium-directed epoxidation. Thus, TCCA N-debenzylation is described for the first time and might be a useful N-debenzylation technique.
Objective:To investigate the sodium dichloroisocyanurate and Trichloroisocyanuric Acid (TCCA) bactericidal effect. Methods: Suspension quantitative germicidal test method, the two chlorine disinfectants bactericidal effect compare parallel results containing available chlorine 150 mg / L of sodium dichloroisocyanurate and trichloroisocyanuric acid aqueous suspension of Escherichia coli 5 min, the average killing logarithm values of 6.71 and 7.62, respectively; suspension of the average killing logarithm of Staphylococcus aureus, respectively 5.37 and 6.47. containing available chlorine 200 mg / L of sodium dichloroisocyanurate and TCCA, suspension of Candida albicans 5 min, the average 
killing logarithm values of 4.75 and 6.41, respectively. in containing available chlorine 1500 mg / L of sodium dichloroisocyanurate and TCCA, suspension of Bacillus subtilis effect 10 min, the average killing logarithm values of 2.47 and 7.51, respectively. in the same effective conclusion under chlorine concentration, Trichloroisocyanuric Acid (TCCA) bactericidal effect than sodium dichloroisocyanurate.