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the optimized amount of Trichloroisocyanuric Acid (TCCA)

Reported is a general synthesis of 3-[(trifluoromethyl)thio]-4H-chromen-4-ones 2 from 1-(2′-hydroxyphenyl)-3-dimethylaminoprop-2-enones 1 and the active electrophilic trifluoromethylthio moiety generated from AgSCF3 and trichloroisocyanuric acid (TCCA). This synthetic approach leads to the direct introduction of the SCF3 group into chromen-4-ones, which represents a very desirable technique to produce diverse molecules for the medicinal chemist. 
The screening of reaction conditions showed that the reaction is highly dependent on the solvent; for example, yields in THF were better than in DMF; however, no product was obtained for reactions that were carried out in MeCN, CH2Cl2, DMSO, MTBE or toluene. The reaction also showed dependency on the optimized amount of TCCA (1.5 equiv), and remarkable insensitivity to air and moisture. The synthetic utility of this reaction to synthesize other SCF3-containing heterocycles such as a topopyrone C analogue was also investigated.
With two drugs: DBDMH and Trichloroisocyanuric Acid (TCCA)  (are located 5 concentration gradient) of the peacock fish acute toxicity test, and drug concentrations were recorded at 12 h, 24 h and 48 h fish poisoning symptoms appear and the number of deaths, according to the test fish mortality and time of death, come DBDMH safe concentration for guppy was 4.68 mg / L, the minimum lethal concentration of 47.5 mg / L. TCCA safe concentration guppy is 0.233 mg / L, the minimum lethal concentration of 2.25 mg / L. Experimental results show that: DBDMH safe concentration is much higher than Trichloroisocyanuric Acid (TCCA) in treatment and fish production and use should note the difference in use.