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using trichloroisocyanuric acid (TCCA) as a relatively stable and inexpensive oxidant surprisingly

Direct and oxidative conversion of tetrahydropyranyl and silyl ethers to oximes is described using trichloroisocyanuric acid (TCCA) as a relatively stable and inexpensive oxidant surprisingly in a catalytic amount and hydroxylamine hydrochloride under solvent-free conditions. Oximes can be synthesized from these protected alcohols in the presence of some other functional groups with excellent chemoselectivity using the present tandem catalytic method.
Melanin may interfere with immunohistochemical staining. The goal of this study was to investigate the effects of trichloroisocyanuric acid (TCCA) bleaching, potassium permanganate bleaching, and potassium dichromate bleaching on melanin, tissue antigen, and 3,3′-diaminobenzidine (DAB) using melanin-containing and melanin-free tissue samples. Our results demonstrated that all 3 bleaching methods efficiently bleached melanin and partially destroyed tissue antigen. In addition, potassium permanganate bleaching and potassium dichromate bleaching clearly destroyed DAB, whereas trichloroisocyanuric acid (TCCA) bleaching had no significant effect on DAB. Therefore, neither potassium permanganate nor potassium dichromate is an ideal solution, whereas TCCA might be an ideal solution for melanin bleaching after the immunohistochemical staining of melanin-containing tissues. After immunostaining followed by TCCA bleaching, the melanin could be completely removed in all 120 malignant melanoma tissue sections. Compared with the control, the DAB intensity was clear, and the tissue structure and cellular nuclei were well maintained. It is worth noting that TCCA should be freshly prepared before each experiment, and used within 2 hours of its preparation. In addition, sections should not be incubated with TCCA for over 30 minutes.
To understand the Trichloroisocyanuric Acid (TCCA) disinfection tablets germicidal efficacy and toxicity to suspension quantitative germicidal test and toxicity tests carried out experimental observation. As a result, containing available chlorine 250 mg / L solution of the disinfectant tablets Escherichia coli, Staphylococcus aureus , Pseudomonas aeruginosa 15 min, the killing of the values are> 5.0, for Candida albicans killing logarithm value> 4.0. containing 2500 mg / L available chlorine disinfectant that Bacillus subtilis effect of 30 min, killing logarithm value of> 5.0. Pseudomonas aeruginosa energy minimum qualifying test concentration of 500 mg / L. containing 250 mg / L of the disinfectant effect 30 min, kill E. coli on plates of value> containing 3.0 to 1000 mg / L disinfectant effect 15 min, the natural bacteria on the surface of the sterilization value of 1.72 for the disinfection tablets on oral toxicity in mice LD50 of> 5000 mg / kg, belong to the actual non-toxic level;.. small murine bone marrow cell micronucleus test was negative. Conclusion, TCCA disinfection tablets for bacteria and Bacillus subtilis is strong in the killing.