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Using Trichloroisocyanuric Acid (TCCA) as a catalyst under mild condition

A convenient synthesis of sulfonic esters from thiols and disulfides is described. In situ preparation of sulfonyl chlorides from thiols is accomplished by oxidation with trichloroisocyanuric acid (TCCA), tetra-butylammonium chloride (t-Bu4NCl), and water. The sulfonyl chlorides are then further allowed to react with phenol derivatives in the same reaction vessel. Also, a facile synthesis of N-substituted pyrroles by the reaction of hexane-2,5-dione with primary amines has been accomplished using TCCA as a catalyst under mild condition with excellent yields.
The triple novelty consists of using a non-conventional chlorination agent, the Trichloroisocyanuric Acid (TCCA) (C3N3O3Cl3), along with solid acid catalysts (mainly zeolites) in a continuous flow reactor system. Different zeolites and solid acids have been tested in the chlorination of nitrobenzene, chosen as a model deactivated aromatic substrate. A new green chlorination process of deactivated aromatics has been developed, being environmental-friendly and allowing the continuous chlorination of 1.7 kg nitrobenzene/kg catalyst per day.
Trichloroisocyanuric Acid (TCCA) belong to cyanuric acid salts,  in general, it has stable chemical properties, slightly toxic or low toxicity, there was one case in Guangzhou TCCA reported mild poisoning, no occupational poisoning reported, Beijing Chaoyang hospital occupational diseases and poisoning Medicine 2006 March 21 staff treated one case of fish due to improper use of the work process TCCA inhalation may cause pulmonary edema in one case, are as follows.