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Trichloroisocyanuric acid (TCCA) as a mild and efficient catalyst for the trimethylsilylation of alcohols and phenols

Recently, we have read an article, the topic is: Trichloroisocyanuric acid (TCCA) as a mild and efficient catalyst for the trimethylsilylation of alcohols and phenols with hexamethyldisilazane (HMDS) under heterogonous conditions.
Abstract: A novel and efficient method for the trimethylsilylation of various alcohols and phenols with hexamethyldisilazane (HMDS) catalyzed by trichloroisocyanuric acid (TCCA) in good to excellent yields in dichloromethane at room temperature was described. Keywords: Alcohols; Phenols; Trichloroisocyanuric acid; Hexamethyldisilazane; Trimethylsilylation.
Hwever, the toxicity and safety of Trichloroisocyanuric acid (TCCA) should also study. Objective: To study the TCCA toxicity and safety, provide toxicological basis for its production and application. Methods: Forty eight SD rats and rabbits were acute toxicity and skin and eye irritation test. the acute toxicity test results of high-dose group animals loose in the coat after 1h, reduced activity, side, breathing difficulties and other symptoms, all died within 5h.